Endocrine Abstracts

Objective: Abnormal lipid profile is an important risk factor in the development of macrovascular atherosclerotic complications in patients with type 2 diabetes mellitus (T2D). The aim of this study was to investigate the relationship between lipid profile and lipid peroxidation in type 2 diabetics with and without coronary artery disease (CAD).Materials and methods: We studied 80 patients with T2D, 40 with CAD and 40 without CAD. We also studied 50 non-...

Objective: The aim of this study was to test the hypothesis that type 2 diabetes mellitus is associated with increased oxidative stress in Iranian subjects.Materials and methods: The study population consisted of Fifty-nine patients with type 2 diabetes (mean age 62.5±8.7 years). Type 2 diabetes was diagnosed according to the American Diabetes Association criteria. 36 patients had diabetes complications and 23 patients had no complications. For the ...

Introduction: Changes in lifestyle have resulted in an increased number of boese subjects, and obesity is currently an important causative factor of health-related problems in Iran.Aims: To investigate the direct relationship of oxidative stress and antioxidant status with obesity in men.Materials and methods: We measured the plasma levels of malondialdehyde (MDA) as a marker of oxidative stress and vitamin E, glutathione and super...

Height and weight measurement is an important data source in affairs related to growth and development, puberty and nutritional status of children and adolescents. In clinical setting NCHS charts are used in Iran. Although there were significant differences among provinces, between urban and rural children and all the percentiles of growth charts from the data of national health survey in Tehran, in 1990-1992, were substantially below but similar to those of the NCHS charts. I...

Background: Polycystic ovary syndrome (PCOS) is a frequent endocrine and metabolic disorder and the most common cause of infertility occurring in 5–10% of women of reproductive age. The characteristic endocrine abnormalities of PCOS involve hypersecretion of androgens and LH (as a consequence of increased GnRH frequency). Although PCOS signs generally become obvious at puberty, clinical and experimental evidence suggests an intrauterine origin for the syndrome. On the oth...

Introduction: Failure to recognise critically ill patients delays escalation to intensive care units (ICU) and results in increased mortality. Objectively identifying the sickest patients on admission remains challenging for healthcare professionals. This study proposes a novel Metabolic Index as a marker of metabolic disturbance based on a patient’s sodium, potassium and bicarbonate. The Metabolic Index is proposed as a predictor of outcome in patients presenting to A&#3...

Background: Hydrocortisone day curves (HCDCs) are commonly used to assess hydrocortisone replacement for patients with adrenal insufficiency (AI).Methods: HCDCs were obtained for 216 adrenally insufficient patients between 2004 and 2012 at Imperial College Healthcare NHS Trust. The area under the curve (AUC) was calculated for each patient’s day profile. Lipid profiles and glycated haemoglobin (HbA1c) values were recorded for each patient at both th...

Background: Glucocorticoid-induced osteoporosis is one of the major clinical concerns of long-term steroid treatment. Previous studies have shown that immunosuppressive doses of glucocorticoid can lead to osteoporosis. This study investigated whether there is a relationship between cortisol exposure and the development of osteoporosis in patients receiving replacement doses.Methods: Hydrocortisone day curves (HCDCs) performed a...

Background: Hydrocortisone day curves (HCDCs) are commonly used to assess hydrocortisone replacement for patients with adrenal insufficiency (AI).Methods: HCDCs were obtained for 216 adrenally insufficient patients between 2004 and 2012 at Imperial College Healthcare NHS Trust. The area under the curve (AUC) was calculated for each patient’s day profile. Lipid profiles and glycated haemoglobin (HbA1c) values were recorded for each patient at both th...

Background: Glucocorticoid-induced osteoporosis is one of the major clinical concerns of long-term steroid treatment. Previous studies have shown that immunosuppressive doses of glucocorticoid can lead to osteoporosis. This study investigated whether there is a relationship between cortisol exposure and the development of osteoporosis in patients receiving replacement doses.Methods: Hydrocortisone day curves (HCDCs) performed a...